A Novel Aquaporin Subfamily Imports Oxygen and Contributes to Pneumococcal Virulence by Controlling the Production and Release of Virulence Factors.

Hu, Qingqing; Tong, Huichun; Wang, Jing; Ge, Pupu; Zhu, Lin; Liu, Cuihua; Zhang, Jing-Ren; Dong, Xiuzhu

Hu, Qingqing; Tong, Huichun; Wang, Jing; Ge, Pupu; Zhu, Lin; Liu, Cuihua; Zhang, Jing-Ren; Dong, Xiuzhu.

Afiliación

Hu Q; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Tong H; University of Chinese Academy of Sciences, Beijing, China.
Wang J; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Ge P; University of Chinese Academy of Sciences, Beijing, China.
Zhu L; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Beijing, China.
Liu C; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Beijing, China.
Zhang JR; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
Dong X; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

mBio ; 12(4): e0130921, 2021 08 31.

Article en En | MEDLINE | ID: mdl-34399618

Asunto(s)

Acuaporinas/genética; Acuaporinas/metabolismo; Proteínas Bacterianas/metabolismo; Oxígeno/metabolismo; Streptococcus pneumoniae/genética; Streptococcus pneumoniae/patogenicidad; Factores de Virulencia/metabolismo; Animales; Proteínas Bacterianas/genética; Escherichia coli/genética; Escherichia coli/metabolismo; Femenino; Peróxido de Hidrógeno/metabolismo; Macrófagos/microbiología; Macrófagos/patología; Ratones; Ratones Endogámicos BALB C; Células RAW 264.7; Virulencia; Factores de Virulencia/genética

Palabras clave

ROS and RNS resistance; Streptococcus pneumoniae; hydrogen peroxide production; new subfamily of aquaporins; oxygen-transporting aquaporin; pneumolysin release; survival in macrophages; virulence

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxígeno / Streptococcus pneumoniae / Proteínas Bacterianas / Acuaporinas / Factores de Virulencia Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: MBio Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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