Lower blood malondialdehyde is associated with past pesticide exposure: findings in Gulf War illness and healthy controls.
Mil Med Res
; 8(1): 46, 2021 08 17.
Article
en En
| MEDLINE
| ID: mdl-34399857
ABSTRACT
BACKGROUND:
Malondialdehyde (MDA) is a candidate general marker of oxidative stress (OS). We sought to assess the relation of MDA to Gulf War illness (GWI) and to a variety of exposures.METHODS:
This is an observational study involving subjects from Southern California recruited from October 2011 to May 2014. MDA was assessed in 81 participants (41 GWI-cases, 40 controls). General and Gulf-specific exposures were elicited. MDA case-control comparison was restricted to 40 matched pairs. The potential association between MDA and exposures was assessed using regression analyses. Gulf-specific exposures were incorporated into a case-specific model.RESULTS:
Plasma MDA was significantly lower in GWI-cases than controls. Composite pesticide and fuel-solvent exposures negatively predicted MDA in the total sample, as well as in the analyses that included either GWI-cases or controls only. Self-reported exposure to organophosphate (OP) nerve gas was a strong predictor for lower MDA level in veterans with GWI.CONCLUSION:
Past pesticide exposures predicted lower MDA in both veterans with GWI and in healthy controls.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plaguicidas
/
Síndrome del Golfo Pérsico
/
Malondialdehído
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Mil Med Res
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos