Psychologically traumatic stress inducing redox - inflammation interplay; which comes first?
Pharmacol Biochem Behav
; 209: 173254, 2021 10.
Article
en En
| MEDLINE
| ID: mdl-34400213
Evidence suggests the involvement of redox and inflammation fields under conditions of psychological trauma. Factors from immunity, Hypothalamic-Adrenal-Pituitary axis, Kynurenine pathway, Dysglycemia, Glutamatergic systems as well as elements from redox mechanisms participate in a highly complex neurobiological process. Yet, little is known about their interplay. There is evidence suggesting a psychologically traumatic stress induced redox-originated inflammatory activation and vice versa. A holistic approach would suggest a parallel activation of the involved mechanisms with highly tight interdependency. The present report aims at collecting the evidence supporting either directionality of the involved mechanisms, finally suggesting a diagram depicting a synthesis of this interplay.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estrés Psicológico
/
Trauma Psicológico
/
Inflamación
Límite:
Humans
Idioma:
En
Revista:
Pharmacol Biochem Behav
Año:
2021
Tipo del documento:
Article
Pais de publicación:
Estados Unidos