FIO2 Trajectory as a Pragmatic Intermediate Marker in Acute Hypoxic Respiratory Failure.
Respir Care
; 66(10): 1521-1530, 2021 Oct.
Article
en En
| MEDLINE
| ID: mdl-34404689
ABSTRACT
BACKGROUND:
Several markers of oxygenation are used as prognostic markers in acute hypoxemic respiratory failure. Real-world use is limited by the need for invasive measurements and unreliable availability in the electronic health record. A pragmatic, reliable, and accurate marker of acute hypoxemic respiratory failure is needed to facilitate epidemiologic studies, clinical trials, and shared decision-making with patients. [Formula see text] is easily obtained at the bedside and from the electronic health record. The [Formula see text] trajectory may be a valuable marker of recovery in patients with acute hypoxemic respiratory failure.METHODS:
This was a historical cohort study of adult subjects admitted to an ICU with acute hypoxemic respiratory failure secondary to community-acquired pneumonia and/or ARDS.RESULTS:
Our study included 2,670 subjects. [Formula see text] and [Formula see text] were consistently more available than was [Formula see text] in the electronic health record ([Formula see text] vs [Formula see text] vs [Formula see text] 100 vs 100 vs 72.8% on day 1, and 100 vs 99 vs 21% on day 5). A worsening [Formula see text] trajectory was associated with reduced ventilator-free days. From days 2 to 5, every increase in [Formula see text] by 10% from the previous day was associated with fewer ventilator-free days (on day 2 adjusted mean -1.25 [95% CI -1.45 to -1.05] d, P < .001). The [Formula see text] trajectory also provided prognostic information. On days 3 - 5, an increase in [Formula see text] from the previous day was associated with increased ventilator-free days (on day 3 adjusted mean 2.09 (95% CI 1.44-2.74) d; P < .001). [Formula see text] models did not add predictive information compared with models with [Formula see text] alone (on day 2 adjusted [Formula see text] vs [Formula see text] R2 0.122 vs 0.119; and on day 3 0.153 vs 0.163).CONCLUSIONS:
[Formula see text] and [Formula see text] are pragmatic and readily available intermediate prognostic markers in acute hypoxic respiratory failure. The [Formula see text] trajectory in the first 5 d of ICU admission provided important prognostic information (ventilator-free days). Although the [Formula see text] trajectory was also associated with ventilator-free days, it did not provide more information than the [Formula see text] trajectory alone.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndrome de Dificultad Respiratoria
/
Insuficiencia Respiratoria
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Humans
Idioma:
En
Revista:
Respir Care
Año:
2021
Tipo del documento:
Article