Electrochemical borylation of carboxylic acids.

Barton, Lisa M; Chen, Longrui; Blackmond, Donna G; Baran, Phil S

Barton, Lisa M; Chen, Longrui; Blackmond, Donna G; Baran, Phil S.

Afiliación

Barton LM; Department of Chemistry, Scripps Research, La Jolla, CA 92037.
Chen L; Department of Chemistry, Scripps Research, La Jolla, CA 92037.
Blackmond DG; Department of Chemistry, Scripps Research, La Jolla, CA 92037 blackmond@scripps.edu pbaran@scripps.edu.
Baran PS; Department of Chemistry, Scripps Research, La Jolla, CA 92037 blackmond@scripps.edu pbaran@scripps.edu.

Proc Natl Acad Sci U S A ; 118(34)2021 08 24.

Article en En | MEDLINE | ID: mdl-34404720

ABSTRACT

ABSTRACT

A simple electrochemically mediated method for the conversion of alkyl carboxylic acids to their borylated congeners is presented. This protocol features an undivided cell setup with inexpensive carbon-based electrodes and exhibits a broad substrate scope and scalability in both flow and batch reactors. The use of this method in challenging contexts is exemplified with a modular formal synthesis of jawsamycin, a natural product harboring five cyclopropane rings.

Asunto(s)

Ácidos Borónicos/química; Ácidos Carboxílicos/química; Técnicas Electroquímicas/métodos; Electrodos

Palabras clave

electrochemistry; organic synthesis; total synthesis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Borónicos / Ácidos Carboxílicos / Electrodos / Técnicas Electroquímicas Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article

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