Hearing Protection Outcomes of Analog Electrode Arrays Coated with Different Drug-Eluting Polymer Films Implanted into Guinea Pig Cochleae.
Drug Des Devel Ther
; 15: 3443-3450, 2021.
Article
en En
| MEDLINE
| ID: mdl-34413631
ABSTRACT
OBJECTIVE:
To investigate the hearing protection outcomes of different drug-eluting analog electrode arrays implanted into guinea pig cochleae.METHODS:
Sixty guinea pigs were randomly divided into a negative control group and five experimental groups implanted separately with blank (drug carrier), dexamethasone (DXM), aracytine (Ara-C), Ara-C+DXM, and nicotinamide adenine dinucleotide (NAD+) eluting analog electrode arrays. Micro CT was used to supervise the surgical procedure. Auditory brainstem response (ABR) thresholds of the guinea pigs were measured and analyzed. RESULTS ANDCONCLUSIONS:
Compared with the negative control, all other groups showed a significant increase in ABR threshold (p<0.001) after surgery. Among them, there was no obvious difference between the blank (0 vs 90 days 59.70±10.57 vs 64.60±9.47 dB SPL) and the NAD+ group (0 vs 90 days 59.90±9.87 vs 64.70±8.65 dB SPL). On the other hand, the ABR thresholds in the DXM (0 days 58.10±10.73 dB SPL; 90 days 51.70±9.07 dB SPL) and the Ara-C group (0 days 59.00±10.05 dB SPL; 90 days 51.60±8.48 dB SPL) decreased significantly compared with the former two groups (p<0.001). However, the Ara-C+DXM group showed no further benefit (p>0.05). In addition, a significantly higher survival rate of spiral ganglion neurons in cochleae was observed in the Ara-C and/or DXM groups.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Potenciales Evocados Auditivos del Tronco Encefálico
/
Implantes Cocleares
/
Pérdida Auditiva
Límite:
Animals
Idioma:
En
Revista:
Drug Des Devel Ther
Asunto de la revista:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
2021
Tipo del documento:
Article