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Combined Effects of Electric Stimulation and Microgrooves in Cardiac Tissue-on-a-Chip for Drug Screening.
Ren, Li; Zhou, Xingwu; Nasiri, Rohollah; Fang, Jun; Jiang, Xing; Wang, Canran; Qu, Moyuan; Ling, Haonan; Chen, Yihang; Xue, Yumeng; Hartel, Martin C; Tebon, Peyton; Zhang, Shiming; Kim, Han-Jun; Yuan, Xichen; Shamloo, Amir; Dokmeci, Mehmet Remzi; Li, Song; Khademhosseini, Ali; Ahadian, Samad; Sun, Wujin.
Afiliación
  • Ren L; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Zhou X; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Nasiri R; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Fang J; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Jiang X; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Wang C; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Qu M; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Ling H; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Chen Y; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Xue Y; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Hartel MC; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Tebon P; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Zhang S; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Kim HJ; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Yuan X; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Shamloo A; Department of Mechanical Engineering, Sharif University of Technology, Tehran 11365, Iran.
  • Dokmeci MR; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Li S; Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Khademhosseini A; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Ahadian S; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Sun W; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Small Methods ; 4(10)2020 Oct 09.
Article en En | MEDLINE | ID: mdl-34423115
ABSTRACT
Animal models and traditional cell cultures are essential tools for drug development. However, these platforms can show striking discrepancies in efficacy and side effects when compared to human trials. These differences can lengthen the drug development process and even lead to drug withdrawal from the market. The establishment of preclinical drug screening platforms that have higher relevancy to physiological conditions is desirable to facilitate drug development. Here, a heart-on-a-chip platform, incorporating microgrooves and electrical pulse stimulations to recapitulate the well-aligned structure and synchronous beating of cardiomyocytes (CMs) for drug screening, is reported. Each chip is made with facile lithographic and laser-cutting processes that can be easily scaled up to high-throughput format. The maturation and phenotypic changes of CMs cultured on the heart-on-a-chip is validated and it can be treated with various drugs to evaluate cardiotoxicity and cardioprotective efficacy. The heart-on-a-chip can provide a high-throughput drug screening platform in preclinical drug development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Screening_studies Idioma: En Revista: Small Methods Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Screening_studies Idioma: En Revista: Small Methods Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos