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Effect of Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptor Blockers on COVID-19 outcome: A Record Based Observational Study in West Bengal.
Bhattacharyya, Arnab; Halder, Susovan; Mandal, Tanuka; Sadhukhan, Sanjoy Kumar; Samajdar, Shambo Samrat; Tripathi, Santanu K; Pal, Jyotirmoy; Mukhopadhyay, Tanmay; Dutta, Basudeb; Poddar, Gopal; Kabiraj, Manisankar; Halder, Dipa; Chowdhury, Neepa; Agarwal, Amit Kumar.
Afiliación
  • Bhattacharyya A; Sr. Consultant in Dept. of Medicine-North 24 Pgs. District Hospital, Barasat, West Bengal;Corresponding Author.
  • Halder S; Consultant Physician, Kasturi Medical Centre, Thakurpukur, Kolkata, West Bengal.
  • Mandal T; Senior Resident Medicine, RG Kar Medical College, Kolkata, West Bengal.
  • Sadhukhan SK; Dept. of Epidemiology, All India Institute of Hygiene and Public Health, Kolkata, West Bengal.
  • Samajdar SS; Dept. of Clinical and Experimental Pharmacology School of Tropical Medicine, Kolkata, West Bengal.
  • Tripathi SK; Dept. of Clinical and Experimental Pharmacology School of Tropical Medicine, Kolkata, West Bengal.
  • Pal J; Prof. of Medicine, R.G. Kar Medical College, Kolkata, West Bengal.
  • Mukhopadhyay T; Assistant Prof. of Dept. of Cardiology, Burdwan Medical College and Hospital, West Bengal.
  • Dutta B; Ex-Asstt. Prof. of Pediatrics, Medical College, Kolkata, West Bengal.
  • Poddar G; MOIC, Dr. JR Dhar SD Hospital Blood Centre, Bongaon, 24pgs(N).
  • Kabiraj M; MO-CCU-North 24pgs., District Hospital.
  • Halder D; CMO-SAG-ESIC Hospital and ODC-EZ, Joka, Kolkata, West Bengal.
  • Chowdhury N; Consultant Biochemist, Dept. of Clinical Biochemistry and Special Immunology, Suraksha Diagnostic Centre, Kolkata, West Bengal.
  • Agarwal AK; Senior Resident Medicine, North 24 Pgs. District Hospital, Barasat, West Bengal.
J Assoc Physicians India ; 69(7): 11-12, 2021 Jul.
Article en En | MEDLINE | ID: mdl-34431266
BACKGROUND: Since its first identification in December 2019, in WUHAN (CHINA), SARS-COV-2, causative agent of Corona virus pandemic, has affected millions of people worldwide, causing thousands of death. There is much speculation about the interplay between ACEI/ARB and Corona virus infection, as for internalization into host cell SARS-COV-2 binds through S spike protein to ACE-2, aided TMPRSS2. METHODS: A record based observational study has been conducted (data obtained from the clinics of fourteen physicians) in two worst affected districts of West Bengal, to find out the association of ACEI/ARB on patients, suffering from Corona virus infection. The study-protocol has already been approved by Clinical Research Ethics Committee of Calcutta School of Tropical Medicine. (IEC Ref. No: CREC-STM/2020-AS-37) Results: Increasing age, male sex and presence of co-morbidities (viz. Diabetes, COPD) are significantly associated with the occurrence of moderate and severe disease. Drugs (viz. ACEI/ARB), though are associated with less severe disease, have not achieved statistical significance, in the present study. CONCLUSION: Drugs, like ACEI/ARB, should be continued in patients suffering from COVID-19 infection, (if they are already on these drugs).
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de la Enzima Convertidora de Angiotensina / COVID-19 Tipo de estudio: Guideline / Observational_studies Aspecto: Ethics Límite: Humans / Male País/Región como asunto: Asia Idioma: En Revista: J Assoc Physicians India Año: 2021 Tipo del documento: Article Pais de publicación: India
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de la Enzima Convertidora de Angiotensina / COVID-19 Tipo de estudio: Guideline / Observational_studies Aspecto: Ethics Límite: Humans / Male País/Región como asunto: Asia Idioma: En Revista: J Assoc Physicians India Año: 2021 Tipo del documento: Article Pais de publicación: India