Activation and Evasion of Innate Immunity by Gammaherpesviruses.
J Mol Biol
; 434(6): 167214, 2022 03 30.
Article
en En
| MEDLINE
| ID: mdl-34437888
ABSTRACT
Gammaherpesviruses are ubiquitous pathogens that establish lifelong infections in the vast majority of adults worldwide. Importantly, these viruses are associated with numerous malignancies and are responsible for significant human cancer burden. These virus-associated cancers are due, in part, to the ability of gammaherpesviruses to successfully evade the innate immune response throughout the course of infection. In this review, we will summarize the current understanding of how gammaherpesviruses are detected by innate immune sensors, how these viruses evade recognition by host cells, and how this knowledge can inform novel therapeutic approaches for these viruses and their associated diseases.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Gammaherpesvirinae
/
Infecciones por Herpesviridae
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Evasión Inmune
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Inmunidad Innata
Límite:
Humans
Idioma:
En
Revista:
J Mol Biol
Año:
2022
Tipo del documento:
Article