Enhancing Acsl4 in absence of mTORC2/Rictor drove ß-cell dedifferentiation via inhibiting FoxO1 and promoting ROS production.

Cui, Canqi; Li, Tingting; Xie, Yun; Yang, Jie; Fu, Chenyang; Qiu, Yixuan; Shen, Linyan; Ni, Qicheng; Wang, Qidi; Nie, Aifang; Ning, Guang; Wang, Weiqing; Gu, Yanyun

Cui, Canqi; Li, Tingting; Xie, Yun; Yang, Jie; Fu, Chenyang; Qiu, Yixuan; Shen, Linyan; Ni, Qicheng; Wang, Qidi; Nie, Aifang; Ning, Guang; Wang, Weiqing; Gu, Yanyun.

Afiliación

Cui C; Shanghai National Research Centre for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Li T; Shanghai National Research Centre for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xie Y; Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yang J; Shanghai National Research Centre for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Fu C; Shanghai National Research Centre for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qiu Y; Shanghai National Research Centre for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shen L; Shanghai National Research Centre for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ni Q; Shanghai National Research Centre for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wang Q; Shanghai National Research Centre for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Nie A; Shanghai National Research Centre for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ning G; Shanghai National Research Centre for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: gning@sibs.ac.cn.
Wang W; Shanghai National Research Centre for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Gu Y; Shanghai National Research Centre for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: guyanyun@sjtu.edu.cn.

Biochim Biophys Acta Mol Basis Dis ; 1867(12): 166261, 2021 12 01.

Article en En | MEDLINE | ID: mdl-34455055

Asunto(s)

Desdiferenciación Celular/genética; Coenzima A Ligasas/genética; Proteína Forkhead Box O1/genética; Células Secretoras de Insulina/metabolismo; Proteína Asociada al mTOR Insensible a la Rapamicina/genética; Animales; Proliferación Celular/genética; Epigenómica; Regulación de la Expresión Génica/genética; Glutatión Peroxidasa/genética; Humanos; Insulina/genética; Insulina/metabolismo; Células Secretoras de Insulina/patología; Metabolismo de los Lípidos/genética; Diana Mecanicista del Complejo 2 de la Rapamicina/genética; Ratones; Oxigenasas de Función Mixta/genética; Especies Reactivas de Oxígeno/metabolismo; Glutatión Peroxidasa GPX1

Palabras clave

Acsl4; FoxO1; MafA; Pancreatic ß-cell; ROS; mTORC2; ß-cell dedifferentiation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Coenzima A Ligasas / Células Secretoras de Insulina / Desdiferenciación Celular / Proteína Forkhead Box O1 / Proteína Asociada al mTOR Insensible a la Rapamicina Límite: Animals / Humans Idioma: En Revista: Biochim Biophys Acta Mol Basis Dis Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

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