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Local-scale diversity of Yersinia pestis: A case study from Ambohitromby, Ankazobe District, Madagascar.
Ramasindrazana, Beza; Parany, Mamionah N J; Rasoamalala, Fanohinjanaharinirina; Rasoanoro, Mercia; Rahajandraibe, Soloandry; Vogler, Amy J; Sahl, Jason W; Andrianaivoarimanana, Voahangy; Rajerison, Minoarisoa; Wagner, David M.
Afiliación
  • Ramasindrazana B; Institut Pasteur de Madagascar, Antananarivo, Madagascar.
  • Parany MNJ; Domaine Sciences et Technologies, Université d'Antananarivo, Antananarivo, Madagascar.
  • Rasoamalala F; Institut Pasteur de Madagascar, Antananarivo, Madagascar.
  • Rasoanoro M; Domaine Sciences et Technologies, Université d'Antananarivo, Antananarivo, Madagascar.
  • Rahajandraibe S; Institut Pasteur de Madagascar, Antananarivo, Madagascar.
  • Vogler AJ; Domaine Sciences et Technologies, Université d'Antananarivo, Antananarivo, Madagascar.
  • Sahl JW; Institut Pasteur de Madagascar, Antananarivo, Madagascar.
  • Andrianaivoarimanana V; Domaine Sciences et Technologies, Université d'Antananarivo, Antananarivo, Madagascar.
  • Rajerison M; Institut Pasteur de Madagascar, Antananarivo, Madagascar.
  • Wagner DM; Northern Arizona University, Flagstaff, AZ, USA.
Zoonoses Public Health ; 69(1): 61-70, 2022 02.
Article en En | MEDLINE | ID: mdl-34480413
Plague is a re-emerging zoonotic disease and a major public health concern in several portions of the world, especially in Madagascar. We report on the presence of different subtypes of Yersinia pestis co-occurring in the same locality. After confirmation of a human plague case in Ambohitromby Commune (Ankazobe District) via isolation of Y. pestis, we undertook small mammal trapping to identify the circulation of Y. pestis amongst rodents in this locality; blood samples were collected from rodents for seroprevalence analysis. Of the 60 individuals of Rattus rattus captured, one yielded an isolate of Y. pestis, 13 others were positive for F1 antigen of Y. pestis using a rapid diagnostic test, and 4 were PCR positive targeting the caf1 and pla genes; 28/60 (46.7%) of the captured R. rattus were seropositive for Y. pestis. Whole-genome SNP analyses revealed that the two isolates obtained from the human case, and the R. rattus belonged to two different subtypes of Y. pestis (s05 and s13, respectively) that were circulating concurrently in Ambohitromby in 2016. Three Y. pestis subtypes (s03, s05 and s13) have now been isolated from Ambohitromby. Subtype s05 had been persisting there for >10 years but one or both of the other subtypes may have been introduced from the Central Highlands region as they were not observed in previous years (s13) or only observed once previously (s03). High seroprevalence against Y. pestis in R. rattus suggests that a portion of the local murine population may have acquired resistance to Y. pestis. Future research should focus on genomically characterizing Y. pestis strains circulating in Ankazobe District and other plague-endemic regions of Madagascar to better understand the overall phylogeography of Y. pestis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peste / Enfermedades de los Roedores / Yersinia pestis Límite: Animals País/Región como asunto: Africa Idioma: En Revista: Zoonoses Public Health Asunto de la revista: MEDICINA VETERINARIA / SAUDE PUBLICA Año: 2022 Tipo del documento: Article País de afiliación: Madagascar Pais de publicación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peste / Enfermedades de los Roedores / Yersinia pestis Límite: Animals País/Región como asunto: Africa Idioma: En Revista: Zoonoses Public Health Asunto de la revista: MEDICINA VETERINARIA / SAUDE PUBLICA Año: 2022 Tipo del documento: Article País de afiliación: Madagascar Pais de publicación: Alemania