The possible role of methylglyoxal metabolism in cancer.

Alfarouk, Khalid O; Alqahtani, Saad S; Alshahrani, Saeed; Morgenstern, Jakob; Supuran, Claudiu T; Reshkin, Stephan J

Alfarouk, Khalid O; Alqahtani, Saad S; Alshahrani, Saeed; Morgenstern, Jakob; Supuran, Claudiu T; Reshkin, Stephan J.

Afiliación

Alfarouk KO; Department of Evolutionary Pharmacology, and Tumor Metabolism, Hala Alfarouk Cancer Center, Khartoum, Sudan.
Alqahtani SS; Pharmacy Practice Research Unit, Clinical Pharmacy Department, College of Pharmacy, Jazan University, Jazan, KSA.
Alshahrani S; Pharmacology and Toxicology Department, College of Pharmacy, Jazan University, Jazan, KSA.
Morgenstern J; Department of Internal Medicine I, Endocrinology and Metabolism, Heidelberg University, Germany.
Supuran CT; Neurofarba Department, Universita Degli Studi di Firenze, Florence, Italy.
Reshkin SJ; Department of Bioscience, Biotechnology and Biopharmaceutics, University of Bari, Bari, Italy.

J Enzyme Inhib Med Chem ; 36(1): 2010-2015, 2021 Dec.

Article en En | MEDLINE | ID: mdl-34517737

ABSTRACT

ABSTRACT

Tumours reprogram their metabolism to acquire an evolutionary advantage over normal cells. However, not all such metabolic pathways support energy production. An example of these metabolic pathways is the Methylglyoxal (MG) one. This pathway helps maintain the redox state, and it might act as a phosphate sensor that monitors the intracellular phosphate levels. In this work, we discuss the biochemical step of the MG pathway and interrelate it with cancer.

Asunto(s)

Glioxal/metabolismo; Neoplasias/metabolismo; Glioxal/química; Humanos; Estructura Molecular

Palabras clave

Methylglyoxal; cancer; enzyme; pH; redox

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glioxal / Neoplasias Límite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Sudán

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