Carboplatin activates the cGAS-STING pathway by upregulating the TREX-1 (three prime repair exonuclease 1) expression in human melanoma.

Ma, Zhourui; Xiong, Qianwei; Xia, Hongliang; Liu, Wei; Dai, Shu; Cai, Shizhong; Zhu, Zhenhong; Yan, Xiangming

Ma, Zhourui; Xiong, Qianwei; Xia, Hongliang; Liu, Wei; Dai, Shu; Cai, Shizhong; Zhu, Zhenhong; Yan, Xiangming.

Afiliación

Ma Z; Department of Burns and Plastic Surgery, Children's Hospital of Soochow University, Suzhou City, Jiangsu Province, China.
Xiong Q; Department of Urology, Children's Hospital of Soochow University, Suzhou City, Jiangsu Province, China.
Xia H; Department of Urology, Children's Hospital of Soochow University, Suzhou City, Jiangsu Province, China.
Liu W; Department of Burns and Plastic Surgery, Children's Hospital of Soochow University, Suzhou City, Jiangsu Province, China.
Dai S; Department of Urology, Children's Hospital of Soochow University, Suzhou City, Jiangsu Province, China.
Cai S; Department of Child and Adolescent Healthcare, Children's Hospital of Soochow University, Suzhou City, Jiangsu Province, China.
Zhu Z; Department of Burns and Plastic Surgery, Children's Hospital of Soochow University, Suzhou City, Jiangsu Province, China.
Yan X; Department of Surgery, Children's Hospital of Soochow University, Suzhou City, Jiangsu Province, China.

Bioengineered ; 12(1): 6448-6458, 2021 12.

Article en En | MEDLINE | ID: mdl-34519260

Asunto(s)

Carboplatino/farmacología; Exodesoxirribonucleasas/genética; Melanoma; Proteínas de la Membrana/genética; Fosfoproteínas/genética; Transducción de Señal/efectos de los fármacos; Animales; Línea Celular Tumoral; Exodesoxirribonucleasas/metabolismo; Humanos; Masculino; Melanoma/genética; Melanoma/metabolismo; Proteínas de la Membrana/metabolismo; Ratones; Ratones Endogámicos BALB C; Nucleotidiltransferasas/genética; Nucleotidiltransferasas/metabolismo; Fosfoproteínas/metabolismo

Palabras clave

Apoptosis; carboplatin; metastatic melanoma; stimulator of interferon genes (STING); three-prime repair exonuclease 1 (TREX1)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfoproteínas / Transducción de Señal / Carboplatino / Exodesoxirribonucleasas / Melanoma / Proteínas de la Membrana Límite: Animals / Humans / Male Idioma: En Revista: Bioengineered Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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