Beneficial autoimmunity links primary biliary cholangitis to the avoidance of cholangiocarcinoma.
Oncoimmunology
; 10(1): 1968595, 2021.
Article
en En
| MEDLINE
| ID: mdl-34527429
ABSTRACT
It has been an open conundrum why primary sclerosing cholangitis (PSC) is a major risk factor for developing cholangiocarcinoma (CAA), while primary biliary cholangitis (PBC) is not. In mouse models of PSC and PBC, it turned out that the latter condition, an autoimmune disease affecting the bile ducts, reduces transgene-induced cholangiocarcinogenesis, as well as the progression of subcutaneously implanted CCA. This CCA-delaying effect is lost upon depletion of T lymphocytes and involves tumor infiltration by T cell clonotypes that are also found in PBC lesions. Hence, organ-specific autoimmunity may improve immunosurveillance.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de los Conductos Biliares
/
Colangitis Esclerosante
/
Colangiocarcinoma
/
Cirrosis Hepática Biliar
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Oncoimmunology
Año:
2021
Tipo del documento:
Article
País de afiliación:
Francia