4-Flourophenyl-substituted 5H-indeno[1,2-b]pyridinols with enhanced topoisomerase II&#945; inhibitory activity: Synthesis, biological evaluation, and structure-activity relationships.

Kunwar, Surendra; Hwang, Soo-Yeon; Katila, Pramila; Seo, Minjung; Man Kadayat, Tara; Kwon, Youngjoo; Lee, Eung-Seok

4-Flourophenyl-substituted 5H-indeno[1,2-b]pyridinols with enhanced topoisomerase IIα inhibitory activity: Synthesis, biological evaluation, and structure-activity relationships.

Kunwar, Surendra; Hwang, Soo-Yeon; Katila, Pramila; Seo, Minjung; Man Kadayat, Tara; Kwon, Youngjoo; Lee, Eung-Seok.

Afiliación

Kunwar S; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea.
Hwang SY; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Global Top 5 Program, Ewha Womans University, Seoul 120-750, Republic of Korea.
Katila P; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea.
Seo M; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Global Top 5 Program, Ewha Womans University, Seoul 120-750, Republic of Korea.
Man Kadayat T; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea.
Kwon Y; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Global Top 5 Program, Ewha Womans University, Seoul 120-750, Republic of Korea. Electronic address: ykwon@ewha.ac.kr.
Lee ES; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea. Electronic address: eslee@yu.ac.kr.

Bioorg Chem ; 116: 105349, 2021 11.

Article en En | MEDLINE | ID: mdl-34536927

Asunto(s)

Antineoplásicos/farmacología; Indenos/farmacología; Proteínas de Unión a Poli-ADP-Ribosa/antagonistas & inhibidores; Piridinas/farmacología; Inhibidores de Topoisomerasa II/farmacología; Antineoplásicos/síntesis química; Antineoplásicos/química; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; ADN-Topoisomerasas de Tipo II/metabolismo; Relación Dosis-Respuesta a Droga; Ensayos de Selección de Medicamentos Antitumorales; Humanos; Indenos/síntesis química; Indenos/química; Estructura Molecular; Proteínas de Unión a Poli-ADP-Ribosa/metabolismo; Piridinas/síntesis química; Piridinas/química; Relación Estructura-Actividad; Inhibidores de Topoisomerasa II/síntesis química; Inhibidores de Topoisomerasa II/química

Palabras clave

2,4-Diphenyl-5H-indeno[1,2-b]pyridinols; Anti-proliferative activity; Fluorinated group; Hydroxyl group; Structure-activity relationship; Topoisomerase IIα inhibition

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridinas / Inhibidores de Topoisomerasa II / Proteínas de Unión a Poli-ADP-Ribosa / Indenos / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos

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