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Comparative In Vitro Study of Antiherpetic Activity of Echinochrome A and Product of Its Oxidation Dehydroechinochrome.
Iunikhina, O V; Krylova, N V; Mishchenko, N P; Vasileva, E A; Fedoreyev, S A; Shchelkanov, M Yu.
Afiliación
  • Iunikhina OV; G. P. Somov Research Institute of Epidemiology and Microbiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Vladivostok, Russia. olga_iun@inbox.ru.
  • Krylova NV; G. P. Somov Research Institute of Epidemiology and Microbiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Vladivostok, Russia.
  • Mishchenko NP; G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Division of the Russian Academy of Sciences, Vladivostok, Russia.
  • Vasileva EA; G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Division of the Russian Academy of Sciences, Vladivostok, Russia.
  • Fedoreyev SA; G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Division of the Russian Academy of Sciences, Vladivostok, Russia.
  • Shchelkanov MY; G. P. Somov Research Institute of Epidemiology and Microbiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Vladivostok, Russia.
Bull Exp Biol Med ; 171(4): 464-467, 2021 Aug.
Article en En | MEDLINE | ID: mdl-34542750
ABSTRACT
The quinoid pigment echinochrome A isolated from the sea urchin Scaphechinus mirabilis, the product of its oxidation dehydroechinochrome, and structurally similar antiviral agent oxolin were tested for their ability to inhibit plaque formation induced by herpes simplex virus type 1 (HSV-1) in Vero cells. The tested compounds showed significant anti-HSV-1 activity, mainly due to their direct effect on viral particles and on virus attachment to cells. The antiviral efficacy of the test compounds increased in the following order oxolin→echinochrome A→dehydroechinochrome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Naftoquinonas / Herpesvirus Humano 1 Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2021 Tipo del documento: Article País de afiliación: Rusia
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Naftoquinonas / Herpesvirus Humano 1 Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2021 Tipo del documento: Article País de afiliación: Rusia