Small Molecule Metabolites at the Host-Microbiota Interface.
J Immunol
; 207(7): 1725-1733, 2021 10 01.
Article
en En
| MEDLINE
| ID: mdl-34544815
The trillions of bacteria that constitutively colonize the human gut collectively generate thousands of unique small molecules. These microbial metabolites can accumulate both locally and systemically and potentially influence nearly all aspects of mammalian biology, including immunity, metabolism, and even mood and behavior. In this review, we briefly summarize recent work identifying bioactive microbiota metabolites, the means through which they are synthesized, and their effects on host physiology. Rather than offering an exhaustive list of all known bioactive microbial small molecules, we select a few examples from each key class of metabolites to illustrate the diverse impacts of microbiota-derived compounds on the host. In addition, we attempt to address the microbial logic behind specific biotransformations. Finally, we outline current and emerging strategies for identifying previously undiscovered bioactive microbiota metabolites that may shape human health and disease.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Microbiota
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Immunol
Año:
2021
Tipo del documento:
Article
Pais de publicación:
Estados Unidos