The role of water in the confinement of ibuprofen in SBA-15.
J Mater Chem B
; 9(36): 7482-7491, 2021 09 22.
Article
en En
| MEDLINE
| ID: mdl-34551060
ABSTRACT
The introduction of ibuprofen into mesopores of SBA-15 has been accomplished using the melting method. Samples exhibit from 9 to 33% of the hydrophobic drug. They are not toxic to mouse monocyte-macrophage cells and do not stimulate a pro-inflammatory response. The sample with 25% of the drug showed no crystalline ibuprofen and almost filled the mesopores, while the sample with 33% showed a total filling of the mesopores with some crystalline ibuprofen present. By means of 1D (1H, 13C HPDEC, 13C CP MAS) and 2D (1H-1H NOESY) MAS NMR spectroscopy, it has been shown that water coexists with ibuprofen in mesopores and has an impact on the mobility of ibuprofen molecules and their location within the sample (outside or inside mesopores). Studies in the dehydrated state show for the first time that the high mobility of ibuprofen in mesopores is directly connected to the presence of water. Dehydrated samples show slightly slower release rates in comparison to their hydrated counterparts.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Agua
/
Ibuprofeno
/
Dióxido de Silicio
Límite:
Animals
Idioma:
En
Revista:
J Mater Chem B
Año:
2021
Tipo del documento:
Article
País de afiliación:
Polonia