Light-Induced Modulation of Chiral Functions in G-Quadruplex-Photochrome Systems.
J Phys Chem Lett
; 12(39): 9436-9441, 2021 Oct 07.
Article
en En
| MEDLINE
| ID: mdl-34554762
The design of artificially engineered chiral structures has received much attention, but the implementation of dynamic functions to modulate the chiroptical response of the systems is less explored. Here, we present a light-responsive G-quadruplex (G4)-based assembly in which chirality enrichment is induced, tuned, and fueled by molecular switches. In particular, the mirror-image dependence on photoactivated azo molecules, undergoing trans-to-cis isomerization, shows chiral recognition effects on the inherent flexibility and conformational diversity of DNA G4s having distinct handedness (right- and left-handed). Through a detailed experimental and computational analysis, we bring compelling evidence on the binding mode of the photochromes on G4s, and we rationalize the origin of the chirality effect that is associated with the complexation event.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
G-Cuádruplex
/
Colorantes Fluorescentes
/
Luz
Idioma:
En
Revista:
J Phys Chem Lett
Año:
2021
Tipo del documento:
Article
País de afiliación:
Polonia
Pais de publicación:
Estados Unidos