Cancer as a homeostatic challenge: the role of the hypothalamus.
Trends Neurosci
; 44(11): 903-914, 2021 11.
Article
en En
| MEDLINE
| ID: mdl-34561122
ABSTRACT
The initiation, progression, and metastatic spread of cancer elicits diverse changes in systemic physiology. In this way, cancer represents a novel homeostatic challenge to the host system. Here, we discuss how the hypothalamus, a critical brain region involved in homeostasis senses, integrates and responds to cancer-induced changes in physiology. Through this lens, cancer-associated changes in behavior (e.g., sleep disruption) and physiology (e.g., glucocorticoid dysregulation) can be viewed as the result of an inability to re-establish homeostasis. We provide examples at each level (receptor sensing, integration of systemic signals, and efferent regulatory pathways) of how homeostatic organization becomes disrupted across different cancers. Finally, we lay out predictions of this hypothesis and highlight outstanding questions that aim to guide further work in this area.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hipotálamo
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Trends Neurosci
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos