Recognition Interface of the Thrombin Binding Aptamer Requires Antiparallel Topology of the Quadruplex Core.

Svetlova, Julia; Sardushkin, Makar; Kolganova, Natalia; Timofeev, Edward

Svetlova, Julia; Sardushkin, Makar; Kolganova, Natalia; Timofeev, Edward.

Afiliación

Svetlova J; Federal Research and Clinical Center of Physical-Chemical Medicine, 119435 Moscow, Russia.
Sardushkin M; Universal Scientific Education and Research Network (USERN), G-Quadruplexes as INnovative ThERApeutiC Targets (G4-INTERACT), University of Pavia, 27100 Pavia, Italy.
Kolganova N; Department of Chemical and Pharmaceutical Technologies and Biomedical Products, Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia.
Timofeev E; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.

Biomolecules ; 11(9)2021 09 09.

Article en En | MEDLINE | ID: mdl-34572544

Asunto(s)

Aptámeros de Nucleótidos/química; G-Cuádruplex; Trombina/metabolismo; Dicroismo Circular; Desoxiguanosina/química; Humanos; Unión Proteica

Palabras clave

G-quadruplex; loops; modification; quadruplex core; recognition interface; thrombin binding aptamer

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombina / Aptámeros de Nucleótidos / G-Cuádruplex Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biomolecules Año: 2021 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza

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