A novel lanthanide-based NIR-II nanoprobe for lung squamous cell carcinoma identification.
Biomater Sci
; 9(19): 6568-6573, 2021 Sep 28.
Article
en En
| MEDLINE
| ID: mdl-34582537
ABSTRACT
The morbidity and mortality of lung cancer, particularly squamous cell carcinoma and non-small-cell lung cancer (NSCLC), is significantly higher than other malignant tumors. Currently, there is a lack of a real-time, nonradioactive detection method for early-stage squamous non-small-cell lung cancer diagnosis. In this study, we introduced fluorescence imaging in the second near-infrared (NIR-II) window to identify in vivo lung squamous cell carcinoma for the first time. A novel nanoprobe is constructed based on downconversion nanoparticles (DCNPs) with a fluorescence core (NaErF4) and an inert shell (NaYF4) coated via the successive layer-by-layer strategy. The existence of the inert shell reduces the surface defects of DCNPs and inhibits the solvent-quenching effect. Therefore, hydrophilic DCNPs exhibit strong NIR-II fluorescence. After modification with an efficient antibody to the squamous cell carcinoma antigen, DCNPs@anti-SCCA nanoprobes exhibited low cytotoxicity and good biocompatibility. These probes can accurately identify lung squamous carcinoma with high tumor-to-normal-tissue ratio as well as high spatial resolution.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carcinoma de Células Escamosas
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Carcinoma de Pulmón de Células no Pequeñas
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Elementos de la Serie de los Lantanoides
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Nanopartículas
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Neoplasias Pulmonares
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Biomater Sci
Año:
2021
Tipo del documento:
Article