Mass spectrometry enables the discovery of inhibitors of an LPS transport assembly via disruption of protein-protein interactions.
Chem Commun (Camb)
; 57(82): 10747-10750, 2021 Oct 14.
Article
en En
| MEDLINE
| ID: mdl-34585198
ABSTRACT
We developed a native mass spectrometry-based approach to quantify the monomer-dimer equilibrium of the LPS transport protein LptH. We use this method to assess the potency and efficacy of an antimicrobial peptide and small molecule disruptors, obtaining new information on their structure-activity relationships. This approach led to the identification of quinoline-based hit compounds representing the basis for the development of novel LPS transport inhibitors.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptidos
/
Quinolinas
/
Receptores de Lipopolisacáridos
/
Bibliotecas de Moléculas Pequeñas
/
Antiinfecciosos
Límite:
Humans
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Reino Unido