Infant gut strain persistence is associated with maternal origin, phylogeny, and traits including surface adhesion and iron acquisition.
Cell Rep Med
; 2(9): 100393, 2021 09 21.
Article
en En
| MEDLINE
| ID: mdl-34622230
ABSTRACT
Gut microbiome succession affects infant development. However, it remains unclear what factors promote persistence of initial bacterial colonizers in the developing gut. Here, we perform strain-resolved analyses to compare gut colonization of preterm and full-term infants throughout the first year of life and evaluate associations between strain persistence and strain origin as well as genetic potential. Analysis of fecal metagenomes collected from 13 full-term and 9 preterm infants reveals that infants' initially distinct microbiomes converge by age 1 year. Approximately 11% of early colonizers, primarily Bacteroides and Bifidobacterium, persist during the first year of life, and those are more prevalent in full-term, compared with preterm infants. Examination of 17 mother-infant pairs reveals maternal gut strains are significantly more likely to persist in the infant gut than other strains. Enrichment in genes for surface adhesion, iron acquisition, and carbohydrate degradation may explain persistence of some strains through the first year of life.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Filogenia
/
Adhesión Bacteriana
/
Microbioma Gastrointestinal
/
Hierro
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
/
Infant
/
Newborn
Idioma:
En
Revista:
Cell Rep Med
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos