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Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota.
Ahmed, Basma A; Ong, Frank J; Barra, Nicole G; Blondin, Denis P; Gunn, Elizabeth; Oreskovich, Stephan M; Szamosi, Jake C; Syed, Saad A; Hutchings, Emily K; Konyer, Norman B; Singh, Nina P; Yabut, Julian M; Desjardins, Eric M; Anhê, Fernando F; Foley, Kevin P; Holloway, Alison C; Noseworthy, Michael D; Haman, Francois; Carpentier, Andre C; Surette, Michael G; Schertzer, Jonathan D; Punthakee, Zubin; Steinberg, Gregory R; Morrison, Katherine M.
Afiliación
  • Ahmed BA; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Ong FJ; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Barra NG; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Blondin DP; Department of Pediatrics, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Gunn E; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Oreskovich SM; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Szamosi JC; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Syed SA; Faculty of Medicine and Health Sciences, Department of Medicine, Division of Neurology, Centre de recherche du CHUS, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.
  • Hutchings EK; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Konyer NB; Department of Pediatrics, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Singh NP; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Yabut JM; Department of Pediatrics, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Desjardins EM; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Anhê FF; Farncombe Metagenomics Facility, Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Foley KP; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Holloway AC; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Noseworthy MD; Department of Pediatrics, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Haman F; Imaging Research Centre, St. Joseph's Healthcare, Hamilton, ON L8N 4A6, Canada.
  • Carpentier AC; Department of Radiology, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Surette MG; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Schertzer JD; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Punthakee Z; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Steinberg GR; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
  • Morrison KM; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
Cell Rep Med ; 2(9): 100397, 2021 09 21.
Article en En | MEDLINE | ID: mdl-34622234
ABSTRACT
In rodents, lower brown adipose tissue (BAT) activity is associated with greater liver steatosis and changes in the gut microbiome. However, little is known about these relationships in humans. In adults (n = 60), we assessed hepatic fat and cold-stimulated BAT activity using magnetic resonance imaging and the gut microbiota with 16S sequencing. We transplanted gnotobiotic mice with feces from humans to assess the transferability of BAT activity through the microbiota. Individuals with NAFLD (n = 29) have lower BAT activity than those without, and BAT activity is inversely related to hepatic fat content. BAT activity is not related to the characteristics of the fecal microbiota and is not transmissible through fecal transplantation to mice. Thus, low BAT activity is associated with higher hepatic fat accumulation in human adults, but this does not appear to have been mediated through the gut microbiota.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tejido Adiposo Pardo / Enfermedad del Hígado Graso no Alcohólico / Microbioma Gastrointestinal Tipo de estudio: Risk_factors_studies Límite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Rep Med Año: 2021 Tipo del documento: Article País de afiliación: Canadá
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tejido Adiposo Pardo / Enfermedad del Hígado Graso no Alcohólico / Microbioma Gastrointestinal Tipo de estudio: Risk_factors_studies Límite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Rep Med Año: 2021 Tipo del documento: Article País de afiliación: Canadá