Introducing hierarchical hollow MnO2 microspheres as nanozymes for colorimetric determination of captopril.
Anal Bioanal Chem
; 413(28): 7063-7072, 2021 Nov.
Article
en En
| MEDLINE
| ID: mdl-34622321
ABSTRACT
A simple sensor was developed for the colorimetric determination of captopril (CPT). Herein, hierarchical hollow MnO2 microspheres (HH-MnO2) were applied as nanozymes with peroxidase-mimetic activity. Free cation radicals with a strong absorption signal (λmax at 653 nm) were generated via a redox reaction between 3, 3', 5, 5'-tetramethylbenzidine (TMB) and HH-MnO2. Captopril could successfully prevent the generation of blue-colored free cation radicals. The influence of CPT concentration on the absorption of the generated radicals was monitored by UV-Vis spectroscopy. The corresponding linear concentration range was from 1.0 to 30.0 µg mL-1 (4.6-138.1 µmol L-1), and the detection limit was found to be 0.26 µg mL-1 (1.2 µmol L-1). As a practical usage, the developed sensor was effectively utilized to measure the content of CPT in pharmaceutical formulations.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Óxidos
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Inhibidores de la Enzima Convertidora de Angiotensina
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Captopril
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Compuestos de Manganeso
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Colorimetría
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Nanoestructuras
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Microesferas
Idioma:
En
Revista:
Anal Bioanal Chem
Año:
2021
Tipo del documento:
Article
País de afiliación:
Irán