Your browser doesn't support javascript.
loading
Total Synthesis of the Spider-Venom Peptide Hi1a.
Duggan, Nisharnthi M; Saez, Natalie J; Clayton, Daniel; Budusan, Elena; Watson, Emma E; Tucker, Isaac J; Rash, Lachlan D; King, Glenn F; Payne, Richard J.
Afiliación
  • Duggan NM; School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
  • Saez NJ; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, NSW 2006, Australia.
  • Clayton D; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.
  • Budusan E; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, St. Lucia, QLD 4072, Australia.
  • Watson EE; School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
  • Tucker IJ; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, NSW 2006, Australia.
  • Rash LD; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, St. Lucia, QLD 4072, Australia.
  • King GF; School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
  • Payne RJ; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, NSW 2006, Australia.
Org Lett ; 23(21): 8375-8379, 2021 11 05.
Article en En | MEDLINE | ID: mdl-34632783
ABSTRACT
Hi1a is a venom peptide from the Australian funnel-web spider Hadronyche infensa with a complex tertiary structure. Hi1a has neuroprotective and cardioprotective properties due to its potent inhibition of acid-sensing ion channel 1a (ASIC1a) and is currently being pursued as a novel therapy for acute ischemic events. Herein, we describe the total synthesis of Hi1a using native chemical ligation. The synthetic peptide was successfully folded and exhibited similar inhibitory activity on ASIC1a to recombinant Hi1a.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Venenos de Araña Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Venenos de Araña Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Australia