[Stimulation and inhibition of the growth of mice carrying the human growth hormone gene]. / Stimuliatsiia i tormozhenie rosta myshei, nesushchikh gen gormona rosta cheloveka.

ABSTRACT

The human growth hormone gene, containing mouse metallothionein gene promotor, was injected into the male pronuclei of fertilized mouse ova. The progeny of transgenic mice included animals with both accelerated and inhibited growth. Radioimmunochemical analysis has revealed human growth hormone synthesis in both groups of transgenic mice. The molecular weight of the hormone synthesized in liver cells was 25,000 daltons. A possible mechanisms of foreign hormone effect on the growth of transgenic mice is discussed.