Pathogenic BCL11A variants provide insights into the mechanisms of human fetal hemoglobin silencing.

Shen, Yong; Li, Rick; Teichert, Kristian; Montbleau, Kara E; Verboon, Jeffrey M; Voit, Richard A; Sankaran, Vijay G

Shen, Yong; Li, Rick; Teichert, Kristian; Montbleau, Kara E; Verboon, Jeffrey M; Voit, Richard A; Sankaran, Vijay G.

Afiliación

Shen Y; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America.
Li R; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
Teichert K; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America.
Montbleau KE; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
Verboon JM; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America.
Voit RA; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
Sankaran VG; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America.

PLoS Genet ; 17(10): e1009835, 2021 10.

Article en En | MEDLINE | ID: mdl-34634037

Asunto(s)

Hemoglobina Fetal/genética; Silenciador del Gen/fisiología; Mutación/genética; Proteínas Represoras/genética; Anemia de Células Falciformes/genética; Línea Celular Tumoral; Células Cultivadas; Humanos; Células K562; Dedos de Zinc/genética; Talasemia beta/genética

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Represoras / Hemoglobina Fetal / Silenciador del Gen / Mutación Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: PLoS Genet Asunto de la revista: GENETICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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