Macrolipasemia secondary to colon cancer chemotherapy: a case report.
Biochem Med (Zagreb)
; 31(3): 030801, 2021 Oct 15.
Article
en En
| MEDLINE
| ID: mdl-34658648
ABSTRACT
We reported macrolipasemia in a colon cancer patient during the chemotherapy period without any evidence of pancreatitis. A 52-year-old man formerly treated for papillary thyroid carcinoma had elevated a carcinoembryonic antigen (CEA) concentration in the latest control and was diagnosed with colon cancer. Xelox chemotherapy (oxaliplatin and capecitabine) protocol was planned for six months. Interestingly, the lipase activities gradually increased from 30 U/L to 434 U/L, and exceeded three times the upper limit of the reference range (13-60 U/L). There were no symptoms of pancreatitis, and the abdominal computed tomography (CT) scan was also normal. Polyethylene glycol (PEG) recovery % values of serum samples gradually decreased and were 27% in the recent sample before the end of chemotherapy. Interestingly, the serum lipase activity fell a month after chemotherapy, and PEG recovery % increased (39%). We considered the following possibilities (1) macrolipasemia due to chemotherapy drugs, (2) macrolipasemia due to antibodies against chemotherapy drugs.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias del Colon
Tipo de estudio:
Guideline
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Biochem Med (Zagreb)
Año:
2021
Tipo del documento:
Article
País de afiliación:
Turquía