Bi-Functional Peptides as a New Therapeutic Tool for Hepatocellular Carcinoma.
Pharmaceutics
; 13(10)2021 Oct 06.
Article
en En
| MEDLINE
| ID: mdl-34683924
ABSTRACT
BACKGROUND:
The interfering peptides that block protein-protein interactions have been receiving increasing attention as potential therapeutic tools.METHODS:
We measured the internalization and biological effect of four bi-functional tumor-penetrating and interfering peptides into primary hepatocytes isolated from three non-malignant and 11 hepatocellular carcinomas.RESULTS:
These peptides are internalized in malignant hepatocytes but not in non-malignant cells. Furthermore, the degree of peptide internalization correlated with receptor expression level and tumor aggressiveness levels. Importantly, penetration of the peptides iRGD-IP, LinTT1-IP, TT1-IP, and RPARPAR-IP induced apoptosis of the malignant hepatocytes without effect on non-malignant cells.CONCLUSION:
Receptor expression levels correlated with the level of peptide internalization and aggressiveness of the tumor. This study highlights the potential to exploit the expression of tumor-penetrating peptide receptors as a predictive marker of liver tumor aggressiveness. These bi-functional peptides could be developed for personalized tumor treatment.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Pharmaceutics
Año:
2021
Tipo del documento:
Article
País de afiliación:
Francia