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Design and Stability Improvement of Pectin-Based Red Blood Cell-Mimicking Microcapsules for Oxygen Therapeutics.
Phakousonh, Damien; Wang, Yale; Schlicht, Sabrina; Wiskirchen, Sam; Bos, Trevor; Ren, Lixia; Chen, Junhong; Hua, Xiaolin; Lee, Jung; Krishnan, Sasirekha; Suresh, K Shoma; Jaisankar, Abinaya; Ramalingam, Murugan; Zhang, Wujie.
Afiliación
  • Phakousonh D; BioMolecular Engineering Program, Physics and Chemistry Department, Milwaukee School of Engineering, Milwaukee, WI 53202, USA.
  • Wang Y; Mechanical Engineering Department, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA.
  • Schlicht S; BioMolecular Engineering Program, Physics and Chemistry Department, Milwaukee School of Engineering, Milwaukee, WI 53202, USA.
  • Wiskirchen S; BioMolecular Engineering Program, Physics and Chemistry Department, Milwaukee School of Engineering, Milwaukee, WI 53202, USA.
  • Bos T; BioMolecular Engineering Program, Physics and Chemistry Department, Milwaukee School of Engineering, Milwaukee, WI 53202, USA.
  • Ren L; School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China.
  • Chen J; Mechanical Engineering Department, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA.
  • Hua X; Department of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China.
  • Lee J; BioMolecular Engineering Program, Physics and Chemistry Department, Milwaukee School of Engineering, Milwaukee, WI 53202, USA.
  • Krishnan S; Biomaterials and Organ Engineering Group, Centre for Biomaterials, Cellular and Molecular Theranostics, School of Mechanical Engineering, Vellore Institute of Technology, Vellore 632014, TamilNadu, India.
  • Suresh KS; Biomaterials and Organ Engineering Group, Centre for Biomaterials, Cellular and Molecular Theranostics, School of Mechanical Engineering, Vellore Institute of Technology, Vellore 632014, TamilNadu, India.
  • Jaisankar A; Biomaterials and Organ Engineering Group, Centre for Biomaterials, Cellular and Molecular Theranostics, School of Mechanical Engineering, Vellore Institute of Technology, Vellore 632014, TamilNadu, India.
  • Ramalingam M; Biomaterials and Organ Engineering Group, Centre for Biomaterials, Cellular and Molecular Theranostics, School of Mechanical Engineering, Vellore Institute of Technology, Vellore 632014, TamilNadu, India.
  • Zhang W; BioMolecular Engineering Program, Physics and Chemistry Department, Milwaukee School of Engineering, Milwaukee, WI 53202, USA.
J Biomed Nanotechnol ; 17(9): 1798-1805, 2021 Sep 01.
Article en En | MEDLINE | ID: mdl-34688324
ABSTRACT
A pectin-oligochitosan microcapsule system has recently been developed for novel oxygen therapeutic design. To improve the stability of the pectin-oligochitosan microcapsules in physiological conditions, both covalent (glutaraldehyde) and noncovalent (Mn2+ and Ca2+) cross-linkers were tested. The chemistry and morphology of the microcapsules were studied using FTIR and SEM, respectively. Results showed that glutaraldehyde is an effective cross-linker, even at low concentrations and short incubation times, and the glutaraldehyde cross-linking does not negatively impact the morphology of the microcapsules. Moreover, it was confirmed that the hemoglobin could be retained within the microcapsules with a minimal release.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxígeno / Pectinas Idioma: En Revista: J Biomed Nanotechnol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxígeno / Pectinas Idioma: En Revista: J Biomed Nanotechnol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos