VISTA Blockade Aggravates Bone Loss in Experimental Murine Apical Periodontitis.
Front Immunol
; 12: 738586, 2021.
Article
en En
| MEDLINE
| ID: mdl-34691045
ABSTRACT
V-domain Ig suppressor of T cell activation (VISTA) is a novel coinhibitory immune checkpoint molecule that maintains immune homeostasis. The present study explored the role of VISTA in human and murine inflammatory tissues of apical periodontitis (AP). VISTA was upregulated in inflammatory tissues of human AP. In mice, the expression of VISTA gradually increased with the development of mouse experimental apical periodontitis (MAP), the CD3+ T cells, CD11b+ myeloid cells, and FOXP3+ regulatory T cells also gradually accumulated. Moreover, a blockade of VISTA using a mouse in vivo anti-VISTA antibody aggravated periapical bone loss and enhanced the infiltration of immune cells in an experimental mouse periapical periodontitis model. The collective results suggest that VISTA serves as a negative regulator of the development and bone loss of apical periodontitis.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Periodontitis Periapical
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Pérdida de Hueso Alveolar
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Subgrupos de Linfocitos T
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Células Mieloides
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Proceso Alveolar
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Proteínas de la Membrana
/
Anticuerpos
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
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Animals
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Front Immunol
Año:
2021
Tipo del documento:
Article
País de afiliación:
China