Association between Congenital Cytomegalovirus Infection and Brain Injury in Neonates: A Meta-analysis of Cohort Studies.
Behav Neurol
; 2021: 9603660, 2021.
Article
en En
| MEDLINE
| ID: mdl-34691283
ABSTRACT
OBJECTIVE:
To assess association between congenital cytomegalovirus (CMV) infection and brain injury in neonates.METHODS:
The literatures from inception to November 4, 2020, were searched through PubMed, Embase, Cochrane Library, and Web of Science. Heterogeneity test was conducted for each indicator and measured by I 2 statistics. If I 2 ≥ 50%, the random effects model was applied; otherwise, the fixed effects model was used. Sensitivity analysis was performed for all models. Weighed mean difference (WMD) was used as the effect size for measurement data, and risk ratio (RR) was as the effect indicator.RESULTS:
A total of 13 studies, including 4,262 congenital CMV infection neonates, were enrolled in this study. Our results showed that the rate of hearing impairment (RR 2.105, 95% CI (1.115, 3.971), P = 0.002), sensorineural hearing loss (SNHL) (RR 17.051, 95% CI (6.201, 46.886), P < 0.001), and microcephaly (RR 2.283, 95% CI (1.325, 3.935), P =0.003) in neonates infected congenital CMV was higher than that in control group.CONCLUSION:
The risks of hearing impairment, SNHL, and microcephaly in neonates during childhood may be associated with congenital CMV infection. It is necessary to establish neonatal screening programs and comprehensive diagnostic tests for patients to reduce the risk of adverse brain damage to the congenital CMV infection as early as possible and to improve the prognosis of the newborn.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Lesiones Encefálicas
/
Infecciones por Citomegalovirus
/
Pérdida Auditiva Sensorineural
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Humans
/
Newborn
Idioma:
En
Revista:
Behav Neurol
Asunto de la revista:
CIENCIAS DO COMPORTAMENTO
/
NEUROLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
China