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Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects.
AlNajjar, Yasmeen T; Gabr, Moustafa; ElHady, Ahmed K; Salah, Mohamed; Wilms, Gerrit; Abadi, Ashraf H; Becker, Walter; Abdel-Halim, Mohammad; Engel, Matthias.
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  • AlNajjar YT; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt.
  • Gabr M; Department of Radiology, Stanford University, CA, 94305, United States.
  • ElHady AK; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt; School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, New Administrative Capital, Cairo, Egypt.
  • Salah M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts, Cairo, 12451, Egypt.
  • Wilms G; Institute of Pharmacology and Toxicology, Medical Faculty of the RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.
  • Abadi AH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt.
  • Becker W; Institute of Pharmacology and Toxicology, Medical Faculty of the RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.
  • Abdel-Halim M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt. Electronic address: mohammad.abdel-halim@guc.edu.eg.
  • Engel M; Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2.3, D-66123, Saarbrücken, Germany. Electronic address: ma.engel@mx.uni-saarland.de.
Eur J Med Chem ; 227: 113911, 2022 Jan 05.
Article en En | MEDLINE | ID: mdl-34710745
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiazoles / Urea / Proteínas Tirosina Quinasas / Proteínas Serina-Treonina Quinasas / Fármacos Neuroprotectores / Alfa-Sinucleína / Descubrimiento de Drogas Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2022 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiazoles / Urea / Proteínas Tirosina Quinasas / Proteínas Serina-Treonina Quinasas / Fármacos Neuroprotectores / Alfa-Sinucleína / Descubrimiento de Drogas Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2022 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Francia