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Advances and insights in the diagnosis of viral infections.
Dronina, Julija; Samukaite-Bubniene, Urte; Ramanavicius, Arunas.
Afiliación
  • Dronina J; Laboratory of Nanotechnology, Department of Functional Materials and Electronics, Center for Physical Sciences and Technology, Sauletekio av. 3, Vilnius, Lithuania.
  • Samukaite-Bubniene U; Department of Physical Chemistry, Faculty of Chemistry and Geoscience, Vilnius University, Naugarduko str. 24, 03225, Vilnius, Lithuania.
  • Ramanavicius A; Department of Physical Chemistry, Faculty of Chemistry and Geoscience, Vilnius University, Naugarduko str. 24, 03225, Vilnius, Lithuania.
J Nanobiotechnology ; 19(1): 348, 2021 Oct 30.
Article en En | MEDLINE | ID: mdl-34717656
Viral infections are the most common among diseases that globally require around 60 percent of medical care. However, in the heat of the pandemic, there was a lack of medical equipment and inpatient facilities to provide all patients with viral infections. The detection of viral infections is possible in three general ways such as (i) direct virus detection, which is performed immediately 1-3 days after the infection, (ii) determination of antibodies against some virus proteins mainly observed during/after virus incubation period, (iii) detection of virus-induced disease when specific tissue changes in the organism. This review surveys some global pandemics from 1889 to 2020, virus types, which induced these pandemics, and symptoms of some viral diseases. Non-analytical methods such as radiology and microscopy also are overviewed. This review overlooks molecular analysis methods such as nucleic acid amplification, antibody-antigen complex determination, CRISPR-Cas system-based viral genome determination methods. Methods widely used in the certificated diagnostic laboratory for SARS-CoV-2, Influenza A, B, C, HIV, and other viruses during a viral pandemic are outlined. A comprehensive overview of molecular analytical methods has shown that the assay's sensitivity, accuracy, and suitability for virus detection depends on the choice of the number of regions in the viral open reading frame (ORF) genome sequence and the validity of the selected analytical method.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus / Virosis / Técnicas de Laboratorio Clínico Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: J Nanobiotechnology Año: 2021 Tipo del documento: Article País de afiliación: Lituania Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus / Virosis / Técnicas de Laboratorio Clínico Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: J Nanobiotechnology Año: 2021 Tipo del documento: Article País de afiliación: Lituania Pais de publicación: Reino Unido