Brain microvascular smooth muscle expresses class II antigens.
J Immunol
; 138(9): 2960-3, 1987 May 01.
Article
en En
| MEDLINE
| ID: mdl-3471815
ABSTRACT
Mouse (BALB/c) splenic lymphocytes co-cultured in vitro with syngeneic brain-derived microvascular smooth muscle (SM) proliferate and become activated. After subsequent transfer of the activated lymphocytes to a syngeneic host, a vasculitis develops in the host. Investigation of the possible antigen-presenting properties of the cultured SM has resulted in the demonstration of class II (Ia) antigens on the SM. Fluorescence-activated cell sorter analysis has shown that an average of 31% of unstimulated SM cells in culture were positive when stained with an anti-IE of the appropriate haplotype (H2d), and an average of 20% were positive with an anti-IA of the H2d haplotype. Controls consisting of irrelevant antibodies of the same isotype, as well as an anti-IA of the H2s haplotype, were negative. In contrast, BALB/c-derived brain microvascular endothelial cells showed considerably less class II antigen expression (7% for both IA and IE).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Antígenos de Histocompatibilidad Clase II
/
Microcirculación
/
Músculo Liso Vascular
Límite:
Animals
Idioma:
En
Revista:
J Immunol
Año:
1987
Tipo del documento:
Article