Synthesis of a TNF inhibitor, flurbiprofen and an <i>i</i>-Pr analogue in enantioenriched forms by copper-catalyzed propargylic substitution with Grignard reagents.

Takashima, Yuji; Isogawa, Yukari; Tsuboi, Atsuki; Ogawa, Narihito; Kobayashi, Yuichi

Synthesis of a TNF inhibitor, flurbiprofen and an i-Pr analogue in enantioenriched forms by copper-catalyzed propargylic substitution with Grignard reagents.

Takashima, Yuji; Isogawa, Yukari; Tsuboi, Atsuki; Ogawa, Narihito; Kobayashi, Yuichi.

Afiliación

Takashima Y; Department of Biomolecular Engineering, Tokyo Institute of Technology, Nagatsuta-cho 4259, Midori-ku, Yokohama 226-8501, Japan.
Isogawa Y; Department of Biomolecular Engineering, Tokyo Institute of Technology, Nagatsuta-cho 4259, Midori-ku, Yokohama 226-8501, Japan.
Tsuboi A; Department of Applied Chemistry, Meiji University, 1-1-1, Higashimita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan.
Ogawa N; Department of Applied Chemistry, Meiji University, 1-1-1, Higashimita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan.
Kobayashi Y; Department of Biomolecular Engineering, Tokyo Institute of Technology, Nagatsuta-cho 4259, Midori-ku, Yokohama 226-8501, Japan.

Org Biomol Chem ; 19(45): 9906-9909, 2021 11 25.

Article en En | MEDLINE | ID: mdl-34734958

Asunto(s)

Alquinos/química; Cobre/química; Flurbiprofeno/síntesis química; Indicadores y Reactivos/química; Propanoles/química; Factor de Necrosis Tumoral alfa/antagonistas & inhibidores; Catálisis; Flurbiprofeno/química; Flurbiprofeno/farmacología; Estereoisomerismo

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flurbiprofeno / Factor de Necrosis Tumoral alfa / Cobre / Propanoles / Alquinos / Indicadores y Reactivos Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Japón

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