Kr-h1 maintains distinct caste-specific neurotranscriptomes in response to socially regulated hormones.
Cell
; 184(23): 5807-5823.e14, 2021 11 11.
Article
en En
| MEDLINE
| ID: mdl-34739833
ABSTRACT
Behavioral plasticity is key to animal survival. Harpegnathos saltator ants can switch between worker and queen-like status (gamergate) depending on the outcome of social conflicts, providing an opportunity to study how distinct behavioral states are achieved in adult brains. Using social and molecular manipulations in live ants and ant neuronal cultures, we show that ecdysone and juvenile hormone drive molecular and functional differences in the brains of workers and gamergates and direct the transcriptional repressor Kr-h1 to different target genes. Depletion of Kr-h1 in the brain caused de-repression of "socially inappropriate" genes gamergate genes were upregulated in workers, whereas worker genes were upregulated in gamergates. At the phenotypic level, loss of Kr-h1 resulted in the emergence of worker-specific behaviors in gamergates and gamergate-specific traits in workers. We conclude that Kr-h1 is a transcription factor that maintains distinct brain states established in response to socially regulated hormones.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hormigas
/
Sesquiterpenos
/
Conducta Social
/
Proteínas de Insectos
/
Ecdisterona
/
Transcriptoma
/
Jerarquia Social
/
Neuronas
Aspecto:
Determinantes_sociais_saude
Límite:
Animals
Idioma:
En
Revista:
Cell
Año:
2021
Tipo del documento:
Article