Severe Lactic Acidosis in a Critically Ill Child: Think About Thiamine! A Case Report.
J Pediatr Intensive Care
; 10(4): 307-310, 2021 Nov.
Article
en En
| MEDLINE
| ID: mdl-34745706
ABSTRACT
In this article, we presented a teenager, in maintenance chemotherapy for leukemia, who was admitted for digestive symptoms related to a parasitic infection and required nutritional support with parenteral nutrition. After 6 weeks, his condition worsened with refractory shock of presumed septic origin, necessitating extracorporeal membrane oxygenation. Despite hemodynamic stabilization, his lactic acidosis worsened until thiamine supplementation was started. Lactate normalized within 12 hours. Thiamine is an essential coenzyme in aerobic glycolysis, and deficiency leads to lactate accumulation through anaerobic glycolysis. Thiamine deficiency is uncommon in the pediatric population. However, it should be considered in patients at risk of nutritional deficiencies with lactic acidosis of unknown origin.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Pediatr Intensive Care
Año:
2021
Tipo del documento:
Article
País de afiliación:
Suiza