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Effectiveness of a new rutin Cu(II) complex in the prevention of lipid peroxidation and hepatotoxicity in hypercholesterolemic rats.
de Oliveira, Daniel A F; Diniz, Susana N; Pereira, Regina M S; Gonçalves, Ivair D; Rennó, André L; Gorjão, Renata; Vieira, Eduardo G; da C Ferreira, Ana M; Okuyama, Cristina E.
Afiliación
  • de Oliveira DAF; Universidade Anhanguera de São Paulo (UNIAN), São Paulo, Brazil.
  • Diniz SN; Universidade Anhanguera de São Paulo (UNIAN), São Paulo, Brazil.
  • Pereira RMS; Universidade Anhanguera de São Paulo (UNIAN), São Paulo, Brazil.
  • Gonçalves ID; Universidade Anhanguera de São Paulo (UNIAN), São Paulo, Brazil.
  • Rennó AL; Faculty of Pharmacy, Centro Universitário de Jaguariúna (UNIFAJ), Jaguariúna, Brazil.
  • Gorjão R; Faculty of Medicine, Faculdade São Leopoldo Mandic (SLM), Campinas, Brazil.
  • Vieira EG; Program of Interdisciplinary Postgraduate in Health Sciences, Universidade Cruzeiro do Sul (UNICSUL), São Paulo, Brazil.
  • da C Ferreira AM; Institute of Chemistry, Universidade de São Paulo (USP), São Paulo, Brazil.
  • Okuyama CE; Institute of Chemistry, Universidade de São Paulo (USP), São Paulo, Brazil.
J Food Biochem ; 46(3): e13999, 2022 03.
Article en En | MEDLINE | ID: mdl-34747031
A new rutin copper(II) complex (R-Cu2) was prepared and characterized by spectroscopic methods and elemental analysis. The effects of rutin and R-Cu2 were evaluated on the prevention of hypercholesterolemia in animals feed with high-cholesterol diet (HCD) for 8 weeks. The animals (n = 5) were neither fed with HCD nor treated (control group), or were treated with vehicle, 10 mg/kg simvastatin, rutin (16 and 160 µmol/kg), and R-Cu2 (16 and 160 µmol/kg) administered orally. Total cholesterol (TC) levels were significantly increased (p < .01) in all HCD groups. In rutin and R-Cu2 groups, it was observed a discrete, but not significant, TC and LDL-induced increase inhibition compared with vehicle-treated group. R-Cu2 treatment significantly decreased (p < .05) plasma triglycerides compared with the vehicle-treated group. All groups receiving treatments maintained the malondialdehyde at normal levels. Serum NO levels were reduced in animals treated with rutin and R-Cu2 compared with the vehicle-treated group. In addition, the results also showed that the groups treated with rutin and R-Cu2 reduced significantly (p < .01), the number of neutrophils and prevented histological changes in all evaluated liver zones. R-Cu2 group maintained the ALT, AST, and ALP enzymes at normal levels. Thus, the effects of R-Cu2 in modulating inflammation and protecting liver damage were confirmed. PRACTICAL APPLICATIONS: Rutin, a plant-derived flavonoid, is one of phenolic compounds well known as a nutraceutical due to its antioxidant and anti-inflammatory properties. Findings of this study demonstrate the effects of both rutin and R-Cu2 in modulating inflammation and protecting liver damage in hypercholesterolemic rats. However, some effects analyzed became more evident in R-Cu2. Thereby, it was shown that the synthesis of a new flavonoid compound (R-Cu2) could be applied as a nutraceutical benefit option to prevent hypercholesterolemia condition.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Hepática Inducida por Sustancias y Drogas / Hipercolesterolemia / Hepatopatías Límite: Animals Idioma: En Revista: J Food Biochem Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Hepática Inducida por Sustancias y Drogas / Hipercolesterolemia / Hepatopatías Límite: Animals Idioma: En Revista: J Food Biochem Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos