CYP2C9 and 3A4 play opposing roles in bioactivation and detoxification of diphenylamine NSAIDs.

Schleiff, Mary Alexandra; Crosby, Samantha; Blue, Madison; Schleiff, Benjamin Mark; Boysen, Gunnar; Miller, Grover Paul

Schleiff, Mary Alexandra; Crosby, Samantha; Blue, Madison; Schleiff, Benjamin Mark; Boysen, Gunnar; Miller, Grover Paul.

Afiliación

Schleiff MA; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.
Crosby S; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.
Blue M; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.
Schleiff BM; Independent Researcher, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.
Boysen G; Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.
Miller GP; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States. Electronic address: millergroverp@uams.edu.

Biochem Pharmacol ; 194: 114824, 2021 12.

Article en En | MEDLINE | ID: mdl-34748821

Asunto(s)

Antiinflamatorios no Esteroideos/metabolismo; Citocromo P-450 CYP2C9/metabolismo; Citocromo P-450 CYP3A/metabolismo; Difenilamina/metabolismo; Microsomas Hepáticos/efectos de los fármacos; Microsomas Hepáticos/metabolismo; Antiinflamatorios no Esteroideos/toxicidad; Difenilamina/toxicidad; Humanos; Inactivación Metabólica/efectos de los fármacos; Inactivación Metabólica/fisiología; Especificidad por Sustrato/efectos de los fármacos; Especificidad por Sustrato/fisiología

Palabras clave

Bioactivation; Diphenylamine NSAIDs; Liver; Quinone-species metabolites; Reactivity; Toxicity

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microsomas Hepáticos / Antiinflamatorios no Esteroideos / Difenilamina / Citocromo P-450 CYP3A / Citocromo P-450 CYP2C9 Tipo de estudio: Prognostic_studies / Qualitative_research Límite: Humans Idioma: En Revista: Biochem Pharmacol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google