Pre-existing infant antibody-dependent cellular cytotoxicity associates with reduced HIV-1 acquisition and lower morbidity.
Cell Rep Med
; 2(10): 100412, 2021 10 19.
Article
en En
| MEDLINE
| ID: mdl-34755132
ABSTRACT
In humans, pre-existing anti-HIV-1 neutralizing antibodies (nAbs) have not been associated with decreased HIV-1 acquisition. Here, we evaluate antibody-dependent cellular cytotoxicity (ADCC) present in pre-transmission infant and maternal plasma and breast milk (BM) against the contemporaneous maternal HIV-1 variants. HIV-1-exposed uninfected compared with HIV-1-exposed infected infants have higher ADCC and a combination of ADCC and nAb responses against their corresponding mother's strains. ADCC does not correlate with nAbs, suggesting they are independent activities. The infected infants with high ADCC compared with low ADCC, but not those with higher ADCC plus nAbs, have lower morbidity up to 1 year after birth. A higher IgA to IgG ratio, observed in BM supernatants and in a higher proportion of the infected compared with the uninfected infants, associates with lower ADCC. Against the exposure strains, ADCC, more than nAbs, associates with both lower mother-to-child transmission and decreased post-infection infant morbidity.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Anticuerpos Anti-VIH
/
Infecciones por VIH
/
VIH-1
/
Anticuerpos Neutralizantes
/
Citotoxicidad Celular Dependiente de Anticuerpos
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Infant
/
Pregnancy
Idioma:
En
Revista:
Cell Rep Med
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos