Treatment of Nocardia asteroides infection with trimethoprim-sulfamethoxazole.
South Med J
; 71(5): 512-5, 1978 May.
Article
en En
| MEDLINE
| ID: mdl-347585
ABSTRACT
Although sulfonamide therapy has reduced the case fatality rate in infection due to Nocardia asteroides from nearly 100% to 25% to 45% there remains a need for a still more effective chemotherapeutic regimen. We describe three cases of serious infection due to N asteroides treated successfully with trimethoprim-sulfamethoxazole (TMP-SMX) and review an additional 15 cases from the world literature. Trimethoprim and sulfamethoxazole exhibit a synergistic interaction in vitro against N asteroides, and the agent reaches antibacterial concentrations in blood, lung, and the central nervous system. Clinical results have been satisfactory in the limited number of patients treated to date.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sulfametoxazol
/
Trimetoprim
/
Nocardiosis
Límite:
Aged
/
Female
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
South Med J
Año:
1978
Tipo del documento:
Article