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Cell size is a determinant of stem cell potential during aging.
Lengefeld, Jette; Cheng, Chia-Wei; Maretich, Pema; Blair, Marguerite; Hagen, Hannah; McReynolds, Melanie R; Sullivan, Emily; Majors, Kyra; Roberts, Christina; Kang, Joon Ho; Steiner, Joachim D; Miettinen, Teemu P; Manalis, Scott R; Antebi, Adam; Morrison, Sean J; Lees, Jacqueline A; Boyer, Laurie A; Yilmaz, Ömer H; Amon, Angelika.
Afiliación
  • Lengefeld J; David H. Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Cheng CW; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
  • Maretich P; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Blair M; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Hagen H; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • McReynolds MR; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Sullivan E; Department of Chemistry, Princeton University, Princeton, NJ, USA.
  • Majors K; Lewis-Sigler Institute for Integrative Genomics, Princeton, NJ, USA.
  • Roberts C; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Kang JH; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Steiner JD; Max Planck Institute for Biology of Ageing and CECAD, University of Cologne, Cologne, Germany.
  • Miettinen TP; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Manalis SR; Department of Physics, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Antebi A; Max Planck Institute for Biology of Ageing and CECAD, University of Cologne, Cologne, Germany.
  • Morrison SJ; Department II of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
  • Lees JA; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Boyer LA; MRC Laboratory for Molecular Cell Biology, University College London, London, UK.
  • Yilmaz ÖH; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Amon A; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Sci Adv ; 7(46): eabk0271, 2021 Nov 12.
Article en En | MEDLINE | ID: mdl-34767451
Stem cells are remarkably small. Whether small size is important for stem cell function is unknown. We find that hematopoietic stem cells (HSCs) enlarge under conditions known to decrease stem cell function. This decreased fitness of large HSCs is due to reduced proliferation and was accompanied by altered metabolism. Preventing HSC enlargement or reducing large HSCs in size averts the loss of stem cell potential under conditions causing stem cell exhaustion. Last, we show that murine and human HSCs enlarge during aging. Preventing this age-dependent enlargement improves HSC function. We conclude that small cell size is important for stem cell function in vivo and propose that stem cell enlargement contributes to their functional decline during aging.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Sci Adv Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Sci Adv Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos