Associations between onychomycosis and COVID-19 clinical outcomes: a retrospective cohort study from a US metropolitan center.
Arch Dermatol Res
; 314(9): 897-902, 2022 Nov.
Article
en En
| MEDLINE
| ID: mdl-34773138
ABSTRACT
Little is known about the relationship of COVID-19 outcomes with onychomycosis. We investigated the relationship of onychomycosis with COVID-19 outcomes. A retrospective cohort study was performed on SARS-CoV-2 positive adult outpatients or inpatients who had onychomycosis and other skin diseases. Overall, 430 adults were identified with SARS-CoV-2 and a skin disease, including 98 with diagnosed onychomycosis. In bivariable logistic regression models, onychomycosis was associated with increased hospitalization {odds ratio(OR) [95% confidence interval (CI)] 3.56 [2.18-5.80]}, initial inpatient vs. outpatient visits (OR [95% CI] 2.24 [1.35-3.74]), use of oxygen therapy (OR [95% CI] 2.77 [1.60-4.79]), severe-critical vs. asymptomatic-mild severity (OR [95% CI] 2.28 [1.32-3.94]), and death (OR [95% CI] 7.48 [1.83-30.47]) from COVID-19, but not prolonged hospitalization (OR [95% CI] 1.03 [0.47-2.25]). In multivariable models adjusting for socio-demographics, comorbidities, and immunosuppressant medication use, the associations with onychomycosis remained significant for hospitalization, inpatient visits, oxygen therapy, severe-critical COVID-19. Onychomycosis was a significant independent risk factor for COVID-19 severity, hospitalization, and receiving supplemental oxygen therapy.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Onicomicosis
/
COVID-19
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Humans
Idioma:
En
Revista:
Arch Dermatol Res
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos