Virtual screening and in vitro validation identifies the first reported inhibitors of Salmonella enterica HPPK.
RSC Med Chem
; 12(10): 1750-1756, 2021 Oct 20.
Article
en En
| MEDLINE
| ID: mdl-34778775
ABSTRACT
HPPK, which directly precedes DHPS in the folate biosynthetic pathway, is a promising but chronically under-exploited anti-microbial target. Here we report the identification of new S. enterica HPPK inhibitors, offering potential for new resistance circumventing S. enterica therapies as well as avenues for diversifying the current HPPK inhibitor space.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Idioma:
En
Revista:
RSC Med Chem
Año:
2021
Tipo del documento:
Article