PRMT4 inhibitor TP-064 impacts both inflammatory and metabolic processes without changing the susceptibility for early atherosclerotic lesions in male apolipoprotein E knockout mice.

Zhang, Yiheng; Verwilligen, Robin A F; de Boer, Miriam; Sijsenaar, Timothy J P; Van Eck, Miranda; Hoekstra, Menno

PRMT4 inhibitor TP-064 impacts both inflammatory and metabolic processes without changing the susceptibility for early atherosclerotic lesions in male apolipoprotein E knockout mice.

Zhang, Yiheng; Verwilligen, Robin A F; de Boer, Miriam; Sijsenaar, Timothy J P; Van Eck, Miranda; Hoekstra, Menno.

Afiliación

Zhang Y; Division of BioTherapeutics, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Gorlaeus Laboratories, Einsteinweg 55, 2333CC, Leiden, the Netherlands. Electronic address: y.zhang.43@lacdr.leidenuniv.nl.
Verwilligen RAF; Division of BioTherapeutics, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Gorlaeus Laboratories, Einsteinweg 55, 2333CC, Leiden, the Netherlands.
de Boer M; Division of BioTherapeutics, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Gorlaeus Laboratories, Einsteinweg 55, 2333CC, Leiden, the Netherlands.
Sijsenaar TJP; Division of BioTherapeutics, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Gorlaeus Laboratories, Einsteinweg 55, 2333CC, Leiden, the Netherlands.
Van Eck M; Division of BioTherapeutics, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Gorlaeus Laboratories, Einsteinweg 55, 2333CC, Leiden, the Netherlands.
Hoekstra M; Division of BioTherapeutics, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Gorlaeus Laboratories, Einsteinweg 55, 2333CC, Leiden, the Netherlands.

Atherosclerosis ; 338: 23-29, 2021 12.

Article en En | MEDLINE | ID: mdl-34785428

Asunto(s)

Aterosclerosis; Inhibidores Enzimáticos/farmacología; Proteína-Arginina N-Metiltransferasas/antagonistas & inhibidores; Animales; Aterosclerosis/tratamiento farmacológico; Aterosclerosis/genética; Colesterol; Dieta Alta en Grasa; Hígado; Masculino; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados para ApoE

Palabras clave

Atherosclerosis; CARM1; Gene expression; Obesity; PPARgamma

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína-Arginina N-Metiltransferasas / Inhibidores Enzimáticos / Aterosclerosis Límite: Animals Idioma: En Revista: Atherosclerosis Año: 2021 Tipo del documento: Article

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