Are sputum eosinophils associated with a different phenotype in COPD patients? A retrospective study.
Respir Med
; 190: 106672, 2021 12.
Article
en En
| MEDLINE
| ID: mdl-34801800
ABSTRACT
Sputum eosinophilia in Chronic Obstructive Pulmonary Disease (COPD) patients seems to be associated with a better response to inhaled corticosteroids (ICS). To verify if this feature could identify a specific subpopulation of COPD patients, we retrospectively compared functional and inflammatory parameters of 110 COPD patients according to the presence of sputum eosinophilia (>2%). Patient with eosinophilia were characterized by lower dyspnea score, lower functional impairment and lower ICS use, suggesting that airway eosinophilia may be associated to a lower COPD severity and some functional "asthma-like" characteristics, therefore explaining the better response to ICS in this subgroup of patients.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Esputo
/
Enfermedad Pulmonar Obstructiva Crónica
/
Eosinófilos
/
Recuento de Leucocitos
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Respir Med
Año:
2021
Tipo del documento:
Article
País de afiliación:
Italia