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Single-Trajectory Multiple-Target Deep Brain Stimulation for Parkinsonian Mobility and Cognition.
Sasikumar, Sanskriti; Cohn, Melanie; Harmsen, Irene E; Loh, Aaron; Cho, Sang Soo; Sáenz-Farret, Michel; Maciel, Ricardo; Soh, Derrick; Boutet, Alexandre; Germann, Jürgen; Elias, Gavin; Youm, Ariana; Duncan, Katherine; Rowland, Nathan C; Strafella, Antonio P; Kalia, Suneil K; Lozano, Andres M; Fasano, Alfonso.
Afiliación
  • Sasikumar S; Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
  • Cohn M; Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
  • Harmsen IE; Krembil Brain Institute, Toronto, Ontario, Canada.
  • Loh A; Mitchell Goldhar MEG Unit, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
  • Cho SS; Toronto Western Hospital, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada.
  • Sáenz-Farret M; Toronto Western Hospital, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada.
  • Maciel R; Division of Brain, Imaging and Behaviour-Systems Neuroscience, Krembil Brain Institute, UHN, University of Toronto, Toronto, Ontario, Canada.
  • Soh D; Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Republic of Korea.
  • Boutet A; Edmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.
  • Germann J; Movement Disorders Unit, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Elias G; Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia.
  • Youm A; Toronto Western Hospital, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada.
  • Duncan K; Joint Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada.
  • Rowland NC; Toronto Western Hospital, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada.
  • Strafella AP; Toronto Western Hospital, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada.
  • Kalia SK; Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
  • Lozano AM; Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
  • Fasano A; Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Mov Disord ; 37(3): 635-640, 2022 03.
Article en En | MEDLINE | ID: mdl-34806782
ABSTRACT

BACKGROUND:

Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) is an emerging target to potentially treat cognitive dysfunction.

OBJECTIVES:

The aim of this study is to achieve feasibility and safety of globus pallidus pars interna (GPi) and NBM DBS in advanced PD with cognitive impairment.

METHODS:

We performed a phase-II double-blind crossover pilot trial in six participants to assess safety and cognitive measures, the acute effect of NBM stimulation on attention, motor and neuropsychological data at one year, and neuroimaging biomarkers of NBM stimulation.

RESULTS:

NBM DBS was well tolerated but did not improve cognition. GPi DBS improved dyskinesia and motor fluctuations (P = 0.04) at one year. NBM stimulation was associated with reduced right frontal and parietal glucose metabolism (P < 0.01) and increased low- and high-frequency power and functional connectivity. Volume of tissue activated in the left NBM was associated with stable cognition (P < 0.05).

CONCLUSIONS:

Simultaneous GPi and NBM stimulation is safe and improves motor complications. NBM stimulation altered neuroimaging biomarkers but without lasting cognitive improvement. © 2021 International Parkinson and Movement Disorder Society.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Estimulación Encefálica Profunda Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Mov Disord Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Canadá
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Estimulación Encefálica Profunda Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Mov Disord Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Canadá